GHK-Cu – For Research Use Only

Quick Facts

• Purity: 98%+
• Form: Lyophilized powder, 5mg vial
• Storage: −20°C long-term; 2–8°C short-term. Avoid light exposure. Avoid repeated freeze-thaw cycles.
• CAS Number: 49557-75-7
• Molecular Formula: C₁₄H₂₄CuN₆O₄
• Molecular Weight: 403.9 g/mol
• COA: Available upon request

About GHK-Cu (Copper Peptide)

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring tripeptide-copper complex first identified in human plasma, urine, and saliva. It consists of the tripeptide GHK (glycyl-histidyl-lysine) complexed with a copper(II) ion, forming a stable coordination complex. GHK-Cu has been one of the most extensively studied copper peptides in biomedical research over the past four decades, with over 3,000 peer-reviewed studies referencing copper peptide biology in various research contexts.

GHK-Cu demonstrates a remarkably broad biological activity profile in laboratory research. Studies have examined its role as a potent activator of wound healing processes, stimulating the production of collagen, elastin, glycosaminoglycans, and decorin in fibroblast cell culture models. It has also been studied for its effects on matrix metalloproteinase (MMP) regulation, specifically its ability to both stimulate collagen-degrading MMPs (removing damaged tissue) while simultaneously upregulating TIMP (tissue inhibitor of metalloproteinase) expression to rebuild the extracellular matrix — a dual remodeling action of significant interest to tissue biology researchers.

Additional areas of GHK-Cu research include its antioxidant properties (copper-dependent superoxide dismutase activation), anti-inflammatory signaling (downregulation of TNF-alpha and IL-6 in cell culture), nerve regeneration, and its effects on gene expression. Genome-wide studies have suggested GHK-Cu may modulate the expression of over 4,000 human genes, including those associated with inflammation, DNA repair, and mitochondrial function — making it a uniquely compelling compound for gene regulation and systems biology research.

Research Context

• Extracellular matrix biology: collagen I, III, elastin, and GAG synthesis in fibroblast models
• MMP/TIMP regulation and tissue remodeling pathway studies
• Antioxidant mechanisms: SOD activation and reactive oxygen species (ROS) research
• Anti-inflammatory signaling: TNF-α, IL-6, and NF-κB pathway studies
• Neurotrophin and nerve regeneration research
• Gene expression modulation and epigenetic research applications

Compliance & Safety

• Intended Use: Strictly for in vitro research, laboratory analysis, and scientific study.
• Not For: Human consumption, veterinary use, cosmetic applications, or therapeutic use.
• Handling: Use appropriate PPE. Copper complexes may stain; handle with care in laboratory settings.
• Buyer Responsibility: By purchasing you confirm you are a qualified researcher or institution and will comply with all applicable local, state, and federal laws.

Shipping

Orders processed within 2–5 business days. Discreet, unmarked packaging on every order. International shipping available where legally permitted.