Melanotan-2 – For Research Use Only

Quick Facts

• Purity: 98%+
• Form: Lyophilized powder, 10mg vial
• Storage: −20°C long-term; 2–8°C short-term. Protect from light. Avoid repeated freeze-thaw cycles.
• CAS Number: 121062-08-6
• Molecular Formula: C₅₀H₆₉N₁₅O₉
• Molecular Weight: 1024.2 g/mol
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
• COA: Available upon request

About Melanotan-2

Melanotan-2 (MT-2) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). Its structure — Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ — incorporates a lactam bridge between the aspartate and lysine residues, creating a cyclic conformation that dramatically increases proteolytic stability and receptor binding affinity compared to the linear native α-MSH sequence. The incorporation of D-Phe in place of L-Phe and the N-terminal acetyl-norleucine further enhance its pharmacological properties as a research tool.

Melanotan-2 is a non-selective melanocortin receptor agonist with binding affinity across multiple receptor subtypes — primarily MC1R, MC3R, MC4R, and MC5R — which distinguishes its receptor interaction profile from the more MC1R-selective Melanotan-1. This broader receptor engagement profile makes MT-2 a particularly valuable pharmacological tool in research contexts where investigators wish to study the full spectrum of melanocortin receptor biology.

MC4R, in particular, has been the subject of substantial neuroscience and metabolic research interest given its central expression in the hypothalamus and its well-documented roles in energy homeostasis, appetite regulation signaling, and autonomic nervous system function. MC3R research has focused on its role in energy partitioning and immune cell biology. The multi-receptor profile of MT-2 provides researchers with a tool to probe these diverse biological systems simultaneously or to use as a comparator against more selective melanocortin ligands.

Research Context

• Multi-receptor melanocortin pharmacology: MC1R, MC3R, MC4R, MC5R binding studies
• MC4R neurobiology: hypothalamic energy homeostasis and appetite signaling research
• MC3R biology: energy partitioning and immune function research
• Cyclic peptide conformation and proteolytic stability studies
• Comparative SAR studies: MT-2 vs. MT-1 vs. native α-MSH receptor selectivity profiling
• Melanogenesis and pigmentation pathway research via MC1R activation

Compliance & Safety

• Intended Use: Strictly for in vitro research, laboratory analysis, and scientific study.
• Not For: Human consumption, veterinary use, cosmetic applications, or therapeutic use.
• Handling: Protect from light during handling. Use appropriate PPE in laboratory settings.
• Buyer Responsibility: By purchasing you confirm you are a qualified researcher or institution and will comply with all applicable local, state, and federal laws.

Shipping

Orders processed within 2–5 business days. Discreet, unmarked packaging on every order. International shipping available where legally permitted.