Tesamorelin – For Research Use Only

Quick Facts

• Purity: 98%+
• Form: Lyophilized powder, 2mg vial
• Storage: −20°C long-term; 2–8°C short-term. Avoid repeated freeze-thaw cycles.
• CAS Number: 218949-48-5
• Molecular Formula: C₂₂H₂₉N₅O₄S
• Molecular Weight: 451.6 g/mol
• COA: Available upon request

About Tesamorelin

Tesamorelin is a synthetic analogue of endogenous Growth Hormone-Releasing Hormone (GHRH), consisting of the full 44 amino acid sequence of human GHRH with a trans-3-hexenoic acid modification at the N-terminus. This structural modification significantly enhances the peptide stability against plasma dipeptidyl peptidase IV (DPP-IV) degradation, making it a highly valuable compound for research into GHRH receptor biology and growth hormone (GH) axis regulation.

In research settings, Tesamorelin binds selectively to GHRH receptors located on somatotroph cells of the anterior pituitary. Upon receptor binding, it stimulates the release of endogenous growth hormone in a physiologically pulsatile manner, consistent with natural GHRH-driven GH secretion. This preserves normal negative feedback mechanisms involving somatostatin, which distinguishes it from direct GH administration in research contexts.

Scientific research involving Tesamorelin has explored its role in pituitary receptor pharmacology, hypothalamic-pituitary-somatotropic (HPS) axis signaling, IGF-1 expression dynamics, and adipose tissue biology — particularly visceral adipose metabolism. The compound has been used in translational research examining the interplay between GH pulsatility, body composition, and metabolic markers.

Research Context

• GHRH receptor binding and downstream cAMP/PKA signaling cascade studies
• Pulsatile GH release kinetics and anterior pituitary biology
• IGF-1 axis regulation and somatotropic signaling research
• Visceral adipose tissue biology and lipolytic pathway research
• DPP-IV stability studies and peptide half-life optimization research

Compliance & Safety

• Intended Use: Strictly for in vitro research, laboratory analysis, and scientific study.
• Not For: Human consumption, veterinary use, cosmetic applications, or therapeutic use.
• Handling: Use appropriate PPE. Handle in a controlled laboratory environment.
• Buyer Responsibility: By purchasing you confirm you are a qualified researcher or institution and will comply with all applicable local, state, and federal laws.

Shipping

Orders processed within 2–5 business days. Discreet, unmarked packaging on every order. International shipping available where legally permitted.