CJC-1295 with DAC – For Research Use Only

Quick Facts

• Purity: 98%+
• Form: Lyophilized powder, 2mg vial
• Storage: −20°C long-term; 2–8°C short-term. Avoid repeated freeze-thaw cycles.
• CAS Number: 863288-34-0
• Molecular Formula: C₁₆₄H₂₆₉N₄₇O₄₉S
• Molecular Weight: ~3647 Da
• COA: Available upon request

About CJC-1295 with DAC

CJC-1295 with DAC (Drug Affinity Complex) is a synthetically modified tetrasubstituted 30-amino acid peptide analogue of GHRH (Growth Hormone-Releasing Hormone). The defining feature of this compound is the incorporation of a Drug Affinity Complex (DAC) technology — a lysine residue modified with a maleimidoproprionic acid (MPA) linker that enables the peptide to form a covalent bond with circulating serum albumin.

This albumin-binding mechanism is of particular scientific interest because it dramatically extends the in vivo half-life of the peptide compared to unmodified GHRH analogues. Unmodified GHRH has a plasma half-life of only a few minutes due to rapid DPP-IV cleavage; CJC-1295 without DAC extends this to several hours, while CJC-1295 with DAC extends the active research window to several days by exploiting the long circulatory half-life of serum albumin (~19 days).

In research settings, CJC-1295 with DAC has been studied for its sustained stimulation of GHRH receptors on pituitary somatotrophs, resulting in prolonged elevation of GH secretion and downstream IGF-1 expression. Researchers have used this compound to study long-acting GHRH analogues in the context of GH axis biology, somatotropic signaling kinetics, and the pharmacokinetic principles of albumin-binding peptide drug delivery systems.

Research Context

• Albumin-binding peptide pharmacokinetics and half-life extension mechanisms
• Long-acting GHRH analogue biology and pituitary receptor saturation studies
• Sustained GH secretion kinetics vs. pulsatile release pattern research
• IGF-1 axis regulation over extended time horizons
• DAC conjugation chemistry and its applications in peptide drug delivery research

Compliance & Safety

• Intended Use: Strictly for in vitro research, laboratory analysis, and scientific study.
• Not For: Human consumption, veterinary use, cosmetic applications, or therapeutic use.
• Handling: Use appropriate PPE. Handle in a controlled laboratory environment.
• Buyer Responsibility: By purchasing you confirm you are a qualified researcher or institution and will comply with all applicable local, state, and federal laws.

Shipping

Orders processed within 2–5 business days. Discreet, unmarked packaging on every order. International shipping available where legally permitted.