Ipamorelin – For Research Use Only

Quick Facts

• Purity: 98%+
• Form: Lyophilized powder, 5mg vial
• Storage: −20°C long-term; 2–8°C short-term. Avoid repeated freeze-thaw cycles.
• CAS Number: 170851-70-4
• Molecular Formula: C₃₈H₄₉N₉O₅
• Molecular Weight: 711.9 g/mol
• Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH₂
• COA: Available upon request

About Ipamorelin

Ipamorelin is a synthetic pentapeptide and selective growth hormone secretagogue (GHS) that acts as an agonist at the ghrelin receptor (GHS-R1a). Its sequence — Aib-His-D-2Nal-D-Phe-Lys-NH₂ — incorporates several non-natural amino acid residues including alpha-aminoisobutyric acid (Aib) and D-2-naphthylalanine (D-2Nal), which confer resistance to enzymatic degradation and contribute to its receptor selectivity profile.

What distinguishes Ipamorelin in GHS research is its high selectivity. Unlike earlier growth hormone secretagogues such as GHRP-2 and GHRP-6, Ipamorelin does not significantly stimulate the release of cortisol, prolactin, or ACTH at research-relevant concentrations, making it a cleaner pharmacological tool for isolating GH axis-specific effects in experimental models. This selectivity makes it particularly valuable in research contexts where investigators wish to study GH release mechanisms without confounding effects on the HPA (hypothalamic-pituitary-adrenal) axis.

In preclinical research, Ipamorelin has been used to study the GHS-R1a receptor signaling cascade, pituitary somatotroph biology, GH pulse amplitude and frequency modulation, and the downstream effects of GH elevation on IGF-1 expression. Its relatively simple pentapeptide structure also makes it a useful model compound for studying peptide-receptor interaction dynamics and structure-activity relationships (SAR) in GHS pharmacology.

Research Context

• GHS-R1a receptor agonism and downstream signaling pathway studies
• Selective GH secretagogue pharmacology vs. non-selective GHS compounds (GHRP-2, GHRP-6)
• Pituitary somatotroph biology and GH pulse modulation research
• IGF-1 axis regulation downstream of GHS-R1a activation
• Structure-activity relationship (SAR) studies for pentapeptide GHS design
• HPA axis selectivity studies comparing GHS compounds

Compliance & Safety

• Intended Use: Strictly for in vitro research, laboratory analysis, and scientific study.
• Not For: Human consumption, veterinary use, cosmetic applications, or therapeutic use.
• Handling: Use appropriate PPE. Handle in a controlled laboratory environment.
• Buyer Responsibility: By purchasing you confirm you are a qualified researcher or institution and will comply with all applicable local, state, and federal laws.

Shipping

Orders processed within 2–5 business days. Discreet, unmarked packaging on every order. International shipping available where legally permitted.